library(dplyr)
library(readr)
library(tidyr)
library(stringr)
library(ggplot2)
library(wesanderson)
library(RColorBrewer)
library(flextable)
library(TwoSampleMR)
ao <- available_outcomes()
rm(dat)
object 'dat' not found
dat <- read_tsv("../query_results/bc_all_mr.tsv") %>%
mutate(outcome = case_when(
outcome.id %in% c('ieu-a-1127','ieu-a-1132', 'ieu-a-1133', 'ieu-a-1134') ~ 'ER+ postmeno',
outcome.id %in% c('ieu-a-1128','ieu-a-1135', 'ieu-a-1136', 'ieu-a-1137') ~ 'ER- premeno',
outcome.id %in% c('ieu-a-1126','ieu-a-1129', 'ieu-a-1130', 'ieu-a-1131') ~ 'Breast cancer (all)',
outcome.id %in% c('ukb-a-519','ukb-a-55') ~ 'ER+ postmeno UKB')) %>%
mutate(chip = case_when(
outcome.id %in% c('ieu-a-1126','ieu-a-1127', 'ieu-a-1128') ~ 'Meta',
outcome.id %in% c('ieu-a-1129', 'ieu-a-1132','ieu-a-1135') ~ 'OncArr',
outcome.id %in% c('ieu-a-1130', 'ieu-a-1133','ieu-a-1136') ~ 'iCOGS',
outcome.id %in% c('ieu-a-1131', 'ieu-a-1134','ieu-a-1137') ~ 'Old',
outcome.id %in% c('ukb-a-519','ukb-a-55') ~ 'UKBB')) %>%
mutate(outcome.details = paste0(outcome.id, " (",format(outcome.sample_size, big.mark = ","))) %>%
separate(outcome.details, into=c('outcome.details', 'tmp'), sep=",") %>%
mutate(outcome.details = gsub("ieu-a-|ukb-a-", '', outcome.details),
outcome.details = paste0(chip, ": ",outcome.details, "K)"))
dat<- dat %>%
mutate(outcome.details = factor(outcome.details, levels= c(
sort(unique(dat$outcome.details)[grepl('Meta', unique(dat$outcome.details))]),
sort(unique(dat$outcome.details)[grepl('OncArr', unique(dat$outcome.details))]),
sort(unique(dat$outcome.details)[grepl('iCOGS', unique(dat$outcome.details))]),
sort(unique(dat$outcome.details)[grepl('Old', unique(dat$outcome.details))]),
sort(unique(dat$outcome.details)[grepl('UKBB', unique(dat$outcome.details))]) ))) %>%
# convert MR results to OR
mutate(loci = mr.b - 1.96 * mr.se,
upci = mr.b + 1.96 * mr.se,
or = exp(mr.b),
or_loci = exp(loci),
or_upci = exp(upci),
OR_CI = paste0(round(or,2), " [",round(or_loci,2) ,":",round(or_upci,2), "]")) %>%
mutate(effect_direction = ifelse(or_loci > 1 & or_upci > 1, 'positive',
ifelse(or_loci < 1 & or_upci < 1, 'negative', 'overlaps null'))) %>%
mutate(mr.b = round(mr.b, 3)) %>%
# subset
filter(exposure.sex != 'Males') %>%
filter(chip!='old') %>%
#filter(mr.pval < 10e-6) %>%
# create categories of exposure traits
# tidy up labels
mutate(exposure = str_replace(exposure.trait, "Treatment/medication code", "Drug"),
exposure = str_replace(exposure, "Non-cancer illness code self-reported", "Illness"),
exposure = str_replace(exposure, "Diagnoses - main ICD10:", "Diagnosis"),
exposure = str_replace(exposure, "Mineral and other dietary supplements:", "Supplements"),
exposure = str_replace(exposure, "Vitamin and mineral supplements:", "Vitamins"),
exposure = str_replace(exposure, "Illness injury bereavement stress in last 2 years", "Stress"),
exposure = str_replace(exposure, "Types of transport used (excluding work)", "Transport"),
exposure = str_replace(exposure, "Types of physical activity in last 4 weeks", "Physical activity")) %>%
mutate(exposure = case_when(grepl("presbyopia", exposure) ~ "Eyesight problems1",
grepl("hypermetropia", exposure) ~ "Eyesight problems2",
TRUE ~ exposure)) %>%
mutate(exposure_cat = case_when(
grepl("Drug", exposure) ~ "drugs",
grepl("Diagnos|Illness|cancer|diagnos|death|disorder|eye|carcino|colitis|disease", exposure, ignore.case = T) ~ "disease",
grepl("vitamin|suppl", exposure, ignore.case = T) ~ "vitamin",
grepl("waist|hip|obesity|trunk|mass|weight|bmi|body size|height|length|impedance", exposure, ignore.case = T) ~ "antrophometric",
grepl("age at|age started", exposure, ignore.case = T) ~ "reproductive",
grepl("alco|wine", exposure, ignore.case = T) ~ "alcohol",
grepl("smok|cigar", exposure, ignore.case = T) ~ "smoking",
grepl("activi|transport|diy", exposure, ignore.case = T) ~ "activity",
TRUE ~ 'other'))
# add notes for trats
exposure_notes <- ao %>% filter(id %in% dat$exposure.id) %>% select(id, note)
dat<- dat %>%
left_join(exposure_notes, by = c('exposure.id'='id')) %>%
# add other exposure details
mutate(exposure = case_when(
exposure.sex == 'Females' ~ paste0(exposure, " (F) ", coalesce(consortium, author),"/" , year),
TRUE ~ paste0(exposure, " (M/F) ", coalesce(consortium, author),"/" , year))) %>%
# add note
mutate(exposure = case_when(grepl('Adjusted for BMI', note) ~ paste0(exposure, " AdjBMI"),
TRUE ~ exposure))
outcome_table<- dat %>%
select(outcome, outcome.id, outcome.sample_size, N_case, chip)%>%
distinct() %>%
arrange(outcome, desc(outcome.sample_size)) %>%
rename(`sample_size`=outcome.sample_size)
set_flextable_defaults(big.mark = " ",
font.size = 10, theme_fun = theme_vanilla,
padding.bottom = 6,
padding.top = 6,
padding.left = 6,
padding.right = 6,
background.color = "#EFEFEF")
ft<-flextable(outcome_table)
ft<-width(ft, j = 1, width=1.5)
ft
outcome | outcome.id | sample_size | N_case | chip |
Breast cancer (all) | ieu-a-1126 | 228 951 | 122 977 | Meta |
Breast cancer (all) | ieu-a-1129 | 106 776 | 61 282 | OncArr |
Breast cancer (all) | ieu-a-1130 | 89 677 | 46 785 | iCOGS |
Breast cancer (all) | ieu-a-1131 | 32 498 | 14 910 | Old |
ER- premeno | ieu-a-1128 | 127 442 | 21 468 | Meta |
ER- premeno | ieu-a-1135 | 55 149 | 9 655 | OncArr |
ER- premeno | ieu-a-1136 | 50 225 | 7 333 | iCOGS |
ER- premeno | ieu-a-1137 | 22 068 | 4 480 | Old |
ER+ postmeno | ieu-a-1127 | 175 475 | 69 501 | Meta |
ER+ postmeno | ieu-a-1132 | 83 691 | 38 197 | OncArr |
ER+ postmeno | ieu-a-1133 | 69 970 | 27 078 | iCOGS |
ER+ postmeno | ieu-a-1134 | 21 814 | 4 226 | Old |
ER+ postmeno UKB | ukb-a-519 | 337 199 | 5 510 | UKBB |
ER+ postmeno UKB | ukb-a-55 | 337 159 | 7 480 | UKBB |
NA
NA
Anthophometric traits
input <- dat %>% filter(exposure_cat %in% c('antrophometric')) %>%
mutate(exposure = gsub("Comparative ", "", exposure))
p<-plot_heatmap(input)
p
input <- dat %>% filter(exposure_cat %in% c('antrophometric')) %>%
mutate(exposure = gsub("Comparative ", "", exposure))
p<-plot_bubble_plot(input)
p

Activity
input <- dat %>% filter(exposure_cat %in% c('activity')) %>%
mutate(exposure = gsub("\\(eg.*)", "", exposure))
p<-plot_heatmap(input)
p
input <- dat %>% filter(exposure_cat %in% c('activity')) %>%
mutate(exposure = gsub("\\(eg.*)", "", exposure))
p<-plot_bubble_plot(input)
p

Supplements / vitamins
input <- dat %>% filter(exposure_cat %in% c('vitamin'))
p<-plot_heatmap(input)
p
input <- dat %>% filter(exposure_cat %in% c('vitamin'))
p<-plot_bubble_plot(input)
p

Reproductive traits
input <- dat %>% filter(exposure_cat %in% c('reproductive')) %>%
mutate(exposure = gsub("\\(eg.*)", "", exposure))
p<-plot_heatmap(input)
p
input <- dat %>% filter(exposure_cat %in% c('reproductive')) %>%
mutate(exposure = gsub("\\(eg.*)", "", exposure))
p<-plot_bubble_plot(input)
p

ply<-plotly::ggplotly(p)
ply
Other
input <- dat %>% filter(exposure_cat %in% c('other')) %>%
filter(!grepl("inhaler", exposure))
p<-plot_heatmap(input)
p
input <- dat %>% filter(exposure_cat %in% c('other')) %>%
filter(!grepl("inhaler", exposure))
p<-plot_bubble_plot(input)
p

Drugs
input <- dat %>% filter(exposure_cat %in% c('drugs'))
p<-plot_bubble_plot(input)
p

Disease
input <- dat %>% filter(exposure_cat %in% c('disease'))
p<-plot_bubble_plot(input)
p

ply<-plotly::ggplotly(p)
Registered S3 method overwritten by 'htmlwidgets':
method from
print.htmlwidget tools:rstudio
ply
---
title: "R Notebook"
output: html_notebook
---

```{r message=F}
library(dplyr)
library(readr)
library(tidyr)
library(stringr)
library(ggplot2)
library(wesanderson)
library(RColorBrewer)
library(flextable)
library(TwoSampleMR)

if (!exists("ao")) {
  ao <- available_outcomes()
}
```


```{r, message = FALSE}
rm(dat)
dat <- read_tsv("../query_results/bc_all_mr.tsv") %>% 
  mutate(outcome = case_when(
        outcome.id %in% c('ieu-a-1127','ieu-a-1132', 'ieu-a-1133', 'ieu-a-1134') ~ 'ER+ postmeno',
        outcome.id %in% c('ieu-a-1128','ieu-a-1135', 'ieu-a-1136', 'ieu-a-1137') ~ 'ER- premeno',
        outcome.id %in% c('ieu-a-1126','ieu-a-1129', 'ieu-a-1130', 'ieu-a-1131') ~ 'Breast cancer (all)',
        outcome.id %in% c('ukb-a-519','ukb-a-55') ~ 'ER+ postmeno UKB')) %>% 
  mutate(chip = case_when(
        outcome.id %in% c('ieu-a-1126','ieu-a-1127', 'ieu-a-1128') ~ 'Meta',
        outcome.id %in% c('ieu-a-1129', 'ieu-a-1132','ieu-a-1135') ~ 'OncArr',
        outcome.id %in% c('ieu-a-1130', 'ieu-a-1133','ieu-a-1136') ~ 'iCOGS',
        outcome.id %in% c('ieu-a-1131', 'ieu-a-1134','ieu-a-1137') ~ 'Old',
        outcome.id %in% c('ukb-a-519','ukb-a-55') ~                  'UKBB')) %>% 
  mutate(outcome.details =  paste0(outcome.id, " (",format(outcome.sample_size, big.mark = ","))) %>% 
  separate(outcome.details, into=c('outcome.details', 'tmp'), sep=",") %>% 
  mutate(outcome.details = gsub("ieu-a-|ukb-a-", '', outcome.details),
         outcome.details = paste0(chip, ": ",outcome.details, "K)"))

dat<- dat %>% 
  mutate(outcome.details = factor(outcome.details, levels= c( 
                    sort(unique(dat$outcome.details)[grepl('Meta', unique(dat$outcome.details))]),
                    sort(unique(dat$outcome.details)[grepl('OncArr', unique(dat$outcome.details))]),
                    sort(unique(dat$outcome.details)[grepl('iCOGS', unique(dat$outcome.details))]),
                    sort(unique(dat$outcome.details)[grepl('Old', unique(dat$outcome.details))]),
                    sort(unique(dat$outcome.details)[grepl('UKBB', unique(dat$outcome.details))])  ))) %>% 
  # convert MR results to OR
  mutate(loci = mr.b - 1.96 * mr.se, 
         upci = mr.b + 1.96 * mr.se,
         or = exp(mr.b), 
         or_loci = exp(loci), 
         or_upci = exp(upci),
         OR_CI = paste0(round(or,2), " [",round(or_loci,2) ,":",round(or_upci,2), "]")) %>% 
  mutate(effect_direction = ifelse(or_loci > 1 & or_upci > 1, 'positive',
                            ifelse(or_loci < 1 & or_upci < 1, 'negative', 'overlaps null'))) %>% 
  mutate(mr.b = round(mr.b, 3)) %>% 
  # subset 
  filter(exposure.sex != 'Males') %>% 
  filter(chip!='old') %>% 
  #filter(mr.pval < 10e-6) %>% 
  # create categories of exposure traits
      # tidy up labels
   mutate(exposure = str_replace(exposure.trait, "Treatment/medication code", "Drug"),
          exposure = str_replace(exposure, "Non-cancer illness code  self-reported", "Illness"),
          exposure = str_replace(exposure, "Diagnoses - main ICD10:", "Diagnosis"),
          exposure = str_replace(exposure, "Mineral and other dietary supplements:", "Supplements"),
          exposure = str_replace(exposure, "Vitamin and mineral supplements:", "Vitamins"),
          exposure = str_replace(exposure, "Illness  injury  bereavement  stress in last 2 years", "Stress"),
          exposure = str_replace(exposure, "Types of transport used (excluding work)", "Transport"),
          exposure = str_replace(exposure, "Types of physical activity in last 4 weeks", "Physical activity")) %>% 
  mutate(exposure = case_when(grepl("presbyopia", exposure) ~ "Eyesight problems1",
                              grepl("hypermetropia", exposure) ~ "Eyesight problems2",
                              TRUE ~ exposure)) %>% 
  mutate(exposure_cat = case_when(
          grepl("Drug", exposure) ~ "drugs",
          grepl("Diagnos|Illness|cancer|diagnos|death|disorder|eye|carcino|colitis|disease", exposure, ignore.case = T) ~ "disease",
          grepl("vitamin|suppl", exposure, ignore.case = T) ~ "vitamin",
          grepl("waist|hip|obesity|trunk|mass|weight|bmi|body size|height|length|impedance", exposure, ignore.case = T) ~ "antrophometric",
          grepl("age at|age started", exposure, ignore.case = T) ~ "reproductive",
          grepl("alco|wine", exposure, ignore.case = T) ~ "alcohol",
          grepl("smok|cigar", exposure, ignore.case = T) ~ "smoking",
          grepl("activi|transport|diy", exposure, ignore.case = T) ~ "activity",
          TRUE ~ 'other')) 
  
# add notes for trats
exposure_notes <- ao %>% filter(id %in% dat$exposure.id) %>% select(id, note)

dat<- dat %>% 
  left_join(exposure_notes, by = c('exposure.id'='id')) %>% 
  # add other exposure details
  mutate(exposure = case_when(
    exposure.sex == 'Females' ~ paste0(exposure, " (F) ", coalesce(consortium, author),"/" , year),
                         TRUE ~ paste0(exposure, " (M/F) ", coalesce(consortium, author),"/" , year))) %>% 
  # add note
  mutate(exposure = case_when(grepl('Adjusted for BMI', note) ~ paste0(exposure, " AdjBMI"),
                        TRUE ~ exposure)) 

```

```{r}
outcome_table<- dat %>% 
  select(outcome, outcome.id, outcome.sample_size, N_case, chip)%>% 
  distinct() %>%
  arrange(outcome, desc(outcome.sample_size)) %>% 
  rename(`sample_size`=outcome.sample_size)


set_flextable_defaults(big.mark = " ", 
  font.size = 10, theme_fun = theme_vanilla,
  padding.bottom = 6, 
  padding.top = 6,
  padding.left = 6,
  padding.right = 6,
  background.color = "#EFEFEF")

ft<-flextable(outcome_table)
ft<-width(ft, j = 1, width=1.5)
ft


```



```{r include=F}
# heatmap function
plot_heatmap <- function(input){
  
  #pal <- wes_palette("Zissou1", 100, type = "continuous")
  limit <- max(abs(input$mr.b)) * c(-1, 1)
  
  colourCount = length(unique(input$mr.b))
  getPalette<-colorRampPalette(rev(brewer.pal(n=7, name = "PiYG")))

  p<-ggplot(input, aes( outcome.details, exposure.trait, fill= mr.b, label = mr.pval, label2 = OR_CI, label3 = exposure.sex)) + 
    scale_fill_gradientn(colours = getPalette(11), limits=limit) + 
    geom_tile()+
    scale_y_discrete(position = "right")+
    facet_grid(exposure_cat~outcome, scales = 'free') +
    theme_bw()+
    theme(axis.text.x=element_text(angle=35, hjust=1), legend.position = 'none')
  return(p)
}

plot_bubble_plot <- function(input){
  
  # first, create a usable p-value variable (truncated and log10-transformed)
  input <- mutate(input, 
            # convert all super small pval into 1e-15
            pval_truncated = ifelse(mr.pval < 1e-15, 1e-15, mr.pval),
            # log transform pvals
            log10pval_trunc = as.integer(-log10(pval_truncated)))
  
  
  #pal <- wes_palette("Zissou1", 100, type = "continuous")
  limit <- max(abs(input$mr.b)) * c(-1, 1)
  
  colourCount = length(unique(input$mr.b))
  getPalette<-colorRampPalette(rev(brewer.pal(n=7, name = "PiYG")))
  
  p<-ggplot(input, aes( outcome.details, reorder(exposure, mr.b), 
                  color= factor(mr.b), size = log10pval_trunc, label2 = OR_CI, label3 = exposure.sex)) + 
    geom_point()+
    scale_size(breaks = c(0,5,7,15))+
    scale_colour_manual(values = getPalette(colourCount))+ # unfair scale + need factor & no legend
    #scale_colour_gradientn(colours = getPalette(11), limits=limit)+ #fair scale
    
    scale_y_discrete(position = "right")+
    facet_grid(exposure_cat~outcome, scales = 'free') +
    theme_light()+
    #theme_solarized()+
    labs(size="-log10(pval)", color='beta', y="", x="")+
    theme(axis.text.x=element_text(angle=35, hjust=1), legend.position = 'left')+
     guides(color = FALSE)
  return(p)
}


```



### Anthophometric traits
```{r fig.width=8}
input <- dat %>% filter(exposure_cat %in% c('antrophometric')) %>% 
   mutate(exposure = gsub("Comparative ", "", exposure)) 

p<-plot_heatmap(input)
p
```


```{r fig.width=10}
input <- dat %>% filter(exposure_cat %in% c('antrophometric')) %>% 
   mutate(exposure = gsub("Comparative ", "", exposure)) 
p<-plot_bubble_plot(input)
p
```

### Activity

```{r fig.width=10, eval=F}
input <- dat %>% filter(exposure_cat %in% c('activity')) %>% 
                mutate(exposure = gsub("\\(eg.*)", "", exposure))
p<-plot_heatmap(input)
p
```


```{r fig.width=10, fig.height=5}
input <- dat %>% filter(exposure_cat %in% c('activity')) %>% 
              mutate(exposure = gsub("\\(eg.*)", "", exposure))
p<-plot_bubble_plot(input)
p
```

### Supplements / vitamins

```{r fig.width=10, eval=F}
input <- dat %>% filter(exposure_cat %in% c('vitamin')) 
p<-plot_heatmap(input)
p
```

```{r fig.width=10, fig.height=5}
input <- dat %>% filter(exposure_cat %in% c('vitamin')) 
p<-plot_bubble_plot(input)
p
```


### Reproductive traits
```{r fig.height=5, eval=F}
input <- dat %>% filter(exposure_cat %in% c('reproductive')) %>% 
                mutate(exposure = gsub("\\(eg.*)", "", exposure))
p<-plot_heatmap(input)
p
```


```{r fig.width=10, fig.height=3}
input <- dat %>% filter(exposure_cat %in%  c('reproductive')) %>% 
                mutate(exposure = gsub("\\(eg.*)", "", exposure))
p<-plot_bubble_plot(input)
p
```

<br>

```{r, eval=F}
ply<-plotly::ggplotly(p)
ply
```


### Other
```{r fig.width=12, eval=F}
input <- dat %>% filter(exposure_cat %in% c('other')) %>% 
                filter(!grepl("inhaler", exposure))
p<-plot_heatmap(input)
p
```


```{r fig.width=15}
input <- dat %>% filter(exposure_cat %in% c('other')) %>% 
                filter(!grepl("inhaler", exposure))
p<-plot_bubble_plot(input)
p
```




### Drugs
```{r fig.width=12}
input <- dat %>% filter(exposure_cat %in% c('drugs')) 
p<-plot_bubble_plot(input)
p
```

### Disease
```{r fig.width=15}
input <- dat %>% filter(exposure_cat %in% c('disease')) 
p<-plot_bubble_plot(input)
p
```

```{r }
ply<-plotly::ggplotly(p)
ply
```

